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Whenever possible, samples shouldbe taken before empirical antibiotics are started. The “empowermentof patients” is a prerequisite for health. An empirical dose aimedat attaining the target level is given in thebeginning and adjustments are made later by actualmonitoring of plasma concentrations An empirical dose aimedat attaining the target level is given in thebeginning and adjustments are made later by actualmonitoring of plasma concentrations.